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musyc_summary_fn

Source: R/musyc_fit_fn.R
musyc_summary_fn.Rd

Summary function for musyc_fit_fn: called once per (drug1 x drug2 x cell line) cell on the fits of all normalization types.

Usage

musyc_summary_fn(fit_dt)

Arguments

fit_dt

data.table of the musyc_fit_fn results for one cell.

Value

Named list with mean_beta, mean_log2_alpha (mean of log2(alpha12) and log2(alpha21), each clipped to [-10, 10]), mean_r2, any_converged and synergy_call ("synergistic", "antagonistic", "additive" or "unknown", from mean_beta with a dead zone of 0.1). synergy_call reflects efficacy only: a pair with strong potency synergy (alpha > 1) and beta near 0 is called "additive", so read it together with mean_log2_alpha.

See also

musyc_fit_fn

Examples

fit_dt <- data.table::data.table(
  normalization_type = c("GR", "RV"), alpha12 = c(2, 1.5),
  alpha21 = c(1.2, 1), beta = c(0.3, 0.2), r2 = c(0.9, 0.95),
  converged = TRUE
)
musyc_summary_fn(fit_dt)
#> $mean_beta
#> [1] 0.25
#> 
#> $mean_log2_alpha
#> [1] 0.4619992
#> 
#> $mean_r2
#> [1] 0.925
#> 
#> $any_converged
#> [1] TRUE
#> 
#> $synergy_call
#> [1] "synergistic"
#>