Changelog

Source: NEWS.md

gDRcore 1.11.13 - 2026-08-19

• add get_period_timepoints() reporting which measurement timepoints enter each growth-rate window, so downstream reports can state the data used instead of only the window bounds

gDRcore 1.11.12 - 2026-08-18

• remove alignment whitespace flagged by the gDRstyle linter
• add @keywords internal to internal helper functions

gDRcore 1.11.11 - 2026-08-17

• add fit_SE.timecourse() two-stage growth-rate fitting for time-course (Incucyte) screens
• add compute_growth_rates() and growth_rates_to_se() as standalone stages, with rate_fn and fit_fn hooks, so the custom fit interface covers time-course data as well
• ensure compute_growth_rates() returns rate_0 on every path, including screens with no control wells, so callers do not have to guard against a missing column

gDRcore 1.11.10 - 2026-08-17

• fix create_SE() for time-course data, where the duration is a nested identifier and therefore absent from the control metadata

gDRcore 1.11.9 - 2026-08-12

• refactor fit_SE.combinations() into composable apply_combo_*() steps

gDRcore 1.11.8 - 2026-08-05

• add apply_custom_fit(), apply_custom_fits(), bliss_fit_fn(), hss_fit_fn(), apply_combo_scores() and composable apply_combo_*() steps
• add fit profile registry (get_fit_profile(), register_fit_profile()) with nested_cols documenting BumpyMatrix row structure per experiment type
• refactor fit_SE() and fit_SE.combinations() as wrappers around apply_fit(); fix non-monotonic (“checkerboard”) response on combo single-agent arms

gDRcore 1.11.7 - 2026-07-29

• add apply_fit_to_se() generic fit-function interface and fit_drug_response_metrics() 3-parameter Hill model matching fit_SE() output
• improve pipeline performance by removing redundant data copies, enabling parallel averaging, and vectorizing NA-filling

gDRcore 1.11.5 - 2026-06-08

• allow custom annotations in merge_data and cleanup_metadata

gDRcore 1.11.4 - 2026-05-27

• apply updated gDRstyle rules

gDRcore 1.11.3 - 2026-05-05

• update author email address

gDRcore 1.11.2 - 2026-05-04

• fix handling of NA Duration in Day0 detection and GR value calculation

gDRcore 1.11.1 - 2026-04-29

• synchronize Bioconductor and GitHub versioning

gDRcore 1.9.8 - 2026-04-27

• fix C++ compilation error on R-devel (STRING_PTR → STRING_PTR_RO)

gDRcore 1.9.7 - 2026-04-13

• migrate from qs to qs2 package (qs::qread → qs2::qs_read, qs::qsave → qs2::qs_save)
• update checkpoint and generated data file extensions from .qs to .qs2

gDRcore 1.9.6 - 2026-02-18

• fix handling of numeric identifiers in annotation functions

gDRcore 1.9.5 - 2026-02-16

• fix stack imbalance warnings during byte-compilation

gDRcore 1.9.4 - 2026-02-02

• remove duplicated code from map_references in map_untreated

gDRcore 1.9.3 - 2025-11-27

• add support for Incucyte data

gDRcore 1.9.2 - 2025-11-17

• remove empty clids from day0 data during merging raw data

gDRcore 1.9.1 - 2025-10-30

• synchronize Bioconductor and GitHub versioning

gDRcore 1.7.8 - 2025-08-12

• fix usage of ifelse

gDRcore 1.7.7 - 2025-07-28

• replace row/col_fittings in source for matrix Metrics assay

gDRcore 1.7.6 - 2025-07-15

• swap drugs to unify combination order

gDRcore 1.7.5 - 2025-07-14

• update headers in fit_SE

gDRcore 1.7.4 - 2025-06-10

• switch from lapply into gDRutils::loop in create_SE

gDRcore 1.7.3 - 2025-05-22

• add functions for reannotating SummarizedExperiment and MultiAssayExperiment objects
• update vignettes

gDRcore 1.7.2 - 2025-05-06

• remove support for masked values

gDRcore 1.7.1 - 2025-04-16

• synchronize Bioconductor and GitHub versioning

gDRcore 1.5.7 - 2025-03-31

• extend the logic of functions for getting annotation from dt to fill missing cols with unknown

gDRcore 1.5.6 - 2025-03-10

• move map_conc_to_standardized_conc to gDRutils package

gDRcore 1.5.5 - 2025-03-05

• update assay names for combo data in get_assays_per_pipeline_step function

gDRcore 1.5.4 - 2025-01-13

• switch to gDRutils::remove_drug_batch function

gDRcore 1.5.3 - 2024-12-18

• fix melt error after changed intersect behaviour

gDRcore 1.5.2 - 2024-11-15

• fix melt in annotation function to fix Bioc error

gDRcore 1.5.1 - 2024-11-05

• synchronize Bioconductor and GitHub versioning

gDRcore 1.3.15 - 2024-10-30

• hotfix annotation colnames of cell lines

gDRcore 1.3.14 - 2024-10-24

• split and refactor annotation functions

gDRcore 1.3.13 - 2024-10-21

• add support for reprocessing data with old data model

gDRcore 1.3.12 - 2024-09-30

• handle properly additional perturbations to get rid of creating additional columns that can’t be hangle properly by the app

gDRcore 1.3.11 - 2024-08-21

• identify additional perturbations hidden in the secondary drug

gDRcore 1.3.10 - 2024-08-19

• utilize calc_sd function

gDRcore 1.3.9 - 2024-08-09

• fix issue with wrong mapping of Day0 data

gDRcore 1.3.8 - 2024-08-08

• fix issue with mapping overrides untreated controls

gDRcore 1.3.7 - 2024-08-05

• fix issue with non-avearaged concentration data

gDRcore 1.3.6 - 2024-07-23

• fix issue with providing empty nested_confounder

gDRcore 1.3.5 - 2024-07-17

• allow using custom functions for calculating HSA and Bliss scores for combination data

gDRcore 1.3.4 - 2024-07-15

• refactor logic for calculating standard deviation for single values

gDRcore 1.3.3 - 2024-07-10

• update unit tests

gDRcore 1.3.2 - 2024-06-04

• switch to get_supported_experiments

gDRcore 1.3.1 - 2024-05-27

• synchronize Bioconductor and GitHub versioning

gDRcore 1.1.22 - 2024-05-16

• move define_matrix_grid_positions and round_concentration functions to gDRutils package

gDRcore 1.1.21 - 2024-05-13

• add functions for retrieving annotation data from input dt

gDRcore 1.1.20 - 2024-05-08

• fix typo

gDRcore 1.1.19 - 2024-04-23

• add vignette with documentation for data annotation

gDRcore 1.1.18 - 2024-04-22

• add support for external annotation specified in the env var

gDRcore 1.1.17 - 2024-03-26

• fix bug with converting mae into raw_data

gDRcore 1.1.16 - 2024-03-15

• remove unstable tests

gDRcore 1.1.15 - 2024-03-14

• clean up package

gDRcore 1.1.14 - 2024-03-12

• update function description

gDRcore 1.1.13 - 2024-02-26

• improve pkgdown site
  • improved references
  • valid NEWS.md

gDRcore 1.1.12 - 2024-02-14

• fix issue with retrieving unique records from mix of control and treated samples

gDRcore 1.1.11 - 2024-02-14

• make documentation compatible with pkdgdown
• rename ‘matches’ to ‘grr_matches’

gDRcore 1.1.10 - 2024-02-12

• fix unit tests for GRAN

gDRcore 1.1.9 - 2024-02-07

• simplify logic of assays for combination data
• rename matrix into combination

gDRcore 1.1.8 - 2024-02-06

• add support for internal source of annotation

gDRcore 1.1.7 - 2024-02-06

• fix bug with converting standardize MAE into raw data

gDRcore 1.1.6 - 2024-02-05

• add vignette for a data model

gDRcore 1.1.5 - 2024-02-01

• update wrappers for co-dilution data

gDRcore 1.1.4 - 2024-01-22

• add new description fields

gDRcore 1.1.3 - 2024-01-04

• improve logic for normalization and identification of single-agent and matrix data with Drug3

gDRcore 1.1.2 - 2023-12-15

• fix issue with wrong assignment of untreated records

gDRcore 1.1.1 - 2023-11-22

• sync master with devel branch
• add support for unifying duplicates in combo matrix data
• add “Treatment” as template identifier

gDRcore 1.1.0 - 2023-10-24

• release Bioc 3.18

gDRcore 1.0.0 - 2023-10-24

• prepare prerelease for Bioc 3.18

gDRcore 0.99.43 - 2023-10-17

• adjust NEWS to Bioc format

gDRcore 0.99.42 - 2023-10-05

• bump version of gDRtestData
• fix bug with merging controls in triple combo with additional perturbations

gDRcore 0.99.41 - 2023-09-25

• add support for adding custom annotations inside input files
• improve the performance

gDRcore 0.99.40 - 2023-09-25

• fix bug with subsetting wrong combo matrix value

gDRcore 0.99.39 - 2023-09-19

• extend the logic for matching missing controls

gDRcore 0.99.38 - 2023-09-12

• set Drug3 as an official tertiary drug in the experiment

gDRcore 0.99.37 - 2023-09-04

• fill NA by average values when there is no match with plate

gDRcore 0.99.36 - 2023-09-01

• fill NA during aggregation of ref and trt data with mean

gDRcore 0.99.35 - 2023-08-17

• fix issue with missing subsetting Day0 data

gDRcore 0.99.34 - 2023-08-16

• update logic for supporting manifest and template files sharing the same column

gDRcore 0.99.33 - 2023-08-10

• update annotation column names for cell line annotation as per changes in the gDRutils

gDRcore 0.99.32 - 2023-07-25

• extend logic for supporting cols with dash, e.g. additional perturbations with “-”

gDRcore 0.99.31 - 2023-07-19

• update the logic for handling warnings in the pipeline

gDRcore 0.99.30 - 2023-07-13

• fix issue with wrong merging of data.tables without nested confounders

gDRcore 0.99.29 - 2023-07-07

• add information about source type for cases without metric data
• refactor the logic for splitting raw data from metadata - get rid of iterative approach

gDRcore 0.99.28 - 2023-07-05

• update logic for parallel computing

gDRcore 0.99.27 - 2023-06-29

• optimize unit tests

gDRcore 0.99.26 - 2023-06-29

• remove backward compatibility for old data model

gDRcore 0.99.25 - 2023-06-27

• fix bug with missing rownames in normalized assay

gDRcore 0.99.24 - 2023-06-19

• update logic for merging data.table objects

gDRcore 0.99.23 - 2023-06-13

• replace order with data.table::setorder

gDRcore 0.99.22 - 2023-06-09

• switch from merge to [[ for data.table objects

gDRcore 0.99.21 - 2023-06-06

• switch from aggregate to data.table

gDRcore 0.99.20 - 2023-06-07

• switch from zoo::rollmean to data.table::frollmean

gDRcore 0.99.19 - 2023-06-06

• replace reshape2 functions by functions from data.table

gDRcore 0.99.18 - 2023-05-31

• fix managing of mixed types of raw data

gDRcore 0.99.17 - 2023-05-29

• fix bug with subsetting data for calculating isobologram

gDRcore 0.99.16 - 2023-05-22

• format the vignette with BiocStyle

gDRcore 0.99.15 - 2023-05-16

• fix related with data.table

gDRcore 0.99.14 - 2023-05-15

• rename excess to x to unify colnames in assay data

gDRcore 0.99.13 - 2023-05-10

• refactor normalization_types in combo-specific assays

gDRcore 0.99.12 - 2023-05-09

• utilize gDRutils::apply_bumpy_function in fit_SE

gDRcore 0.99.11 - 2023-05-05

• fix bug with swapping untreated/vehicle values

gDRcore 0.99.10 - 2023-05-04

• fix bug with data.table

gDRcore 0.99.9 - 2023-04-21

• utilize gDRutils::apply_bumpy_function in average_SE

gDRcore 0.99.8 - 2023-04-20

• switch to OSI license

gDRcore 0.99.7 - 2023-04-19

• fix bug with replacing vehicle to untreated values

gDRcore 0.99.6 - 2023-04-19

• moved wrapper fuctions from gDRtestData

gDRcore 0.99.5 - 2023-04-18

• update dependencies
• add fix for bioc-devel - correct sorting in merge test

gDRcore 0.99.4 - 2023-04-17

• fix namespacing issue in examples
• add R 4.2 as dependency
• fix examples for normalize_SE

gDRcore 0.99.3 - 2023-04-12

• add logic for retrieving raw data from assay data

gDRcore 0.99.2 - 2023-04-07

• update maintainer

gDRcore 0.99.1 - 2023-04-04

• fix the logic in ‘cleanup_metadata’

gDRcore 0.99.0 - 2023-03-24

• make the package Bioc-compatible

gDRcore 0.1.3.22 - 2023-03-21

• improve performance of ‘map_df’ with refactored logic for exact matches

gDRcore 0.1.3.21 - 2023-03-15

• refactor pipeline

gDRcore 0.1.3.20 - 2023-03-09

• address co-treatment fit by using the matrix data type instead

gDRcore 0.1.3.19 - 2023-03-07

• add support for splitting normalization types

gDRcore 0.1.3.18 - 2023-03-06

• improve logic in functions used to generate isobolograms’ data

gDRcore 0.1.3.17 - 2023-03-06

• remove obsolete code

gDRcore 0.1.3.16 - 2023-02-21

• add support for partial pipeline runs

gDRcore 0.1.3.15 - 2023-02-10

• update path to annotation data

gDRcore 0.1.3.14 - 2023-02-10

• clean-up code

gDRcore 0.1.3.13 - 2023-01-13

• clean-up code

gDRcore 0.1.3.12 - 2023-01-12

• refactor mapping function to properly handle drug3

gDRcore 0.1.3.11 - 2022-12-16

• replace parallelize function with gDRutils::loop

gDRcore 0.1.3.10 - 2022-12-15

• add assert for vehicle values in input data in runDrugResponseProcessingPipeline

gDRcore 0.1.3.9 - 2022-12-14

• fix error-handling if conditions in average_SE

gDRcore 0.1.3.8 - 2022-11-07

• fix invalid encapsulation in tests

gDRcore 0.1.3.7 - 2022-10-18

• add missing namespacing

gDRcore 0.1.3.6 - 2022-10-10

• add support for setting number of cores for BiocParallel based on the env variable

gDRcore 0.1.3.5 - 2022-10-07

• remove global parameters for BiocParallel

gDRcore 0.1.3.4 - 2022-09-29

• change the logic for using cores in BiocParallel

gDRcore 0.1.3.3 - 2022-09-27

• update the logic for parallel computing

gDRcore 0.1.3.2 - 2022-08-17

• update the logic for default nested_confounders in create_SE function

gDRcore 0.1.3.1 - 2022-07-08

• refactor create_SE to support reverse single-agent data

gDRcore 0.1.3.0 - 2022-06-02

• release 1.3.0

gDRcore 0.1.1.39 - 2022-05-30

• add missing namespace for get_env_identifiers

gDRcore 0.1.1.38 - 2022-05-09

• replace NA by 0 in Concentration loaded in manifest file

gDRcore 0.1.1.37 - 2022-05-06

• switch from data.table to data.frame in add_annotation* functions

gDRcore 0.1.1.36 - 2022-04-12

• update function for adding unknown cell line annotations
• update logic for using nested confounders
• remove grr from dependencies

gDRcore 0.1.1.35 - 2022-04-07

• get rid of gDRwrapper

gDRcore 0.1.1.34 - 2022-03-30

• add support for additional barcode identifiers

gDRcore 0.1.1.33 - 2022-03-18

• fix documentation in calculate_matrix_metric

gDRcore 0.1.1.32 - 2022-03-17

• switch from catchr to purrr

gDRcore 0.1.1.31 - 2022-03-02

• fix mapping reference values of inverted treatments
• remove duplication of single-agent data

gDRcore 0.1.1.30 - 2022-02-17

• wrap SE into MAE on the level of runDrugResponseProcessingPipeline

gDRcore 0.1.1.29 - 2022-02-14

• change identifier drugname to drug_name

gDRcore 0.1.1.28 - 2022-02-09

• switch from gDRinternal to gDRinternalData for internal annotations

gDRcore 0.1.1.27 - 2022-02-08

• issue with subsetting by list in R 4.2.0

gDRcore 0.1.1.26 - 2022-02-02

• unlist output of intersect as per R 4.2.0

gDRcore 0.1.1.25 - 2022-01-31

• align version criteria between dependencies.yaml and DESCRIPTION package versions

gDRcore 0.1.1.24 - 2022-01-25

• standardize/improve CI

gDRcore 0.1.1.23 - 2022-01-24

• switch from cores variable to detect_cores- function

gDRcore 0.1.1.22 - 2022-01-24

• fix wrong type of NUM_CORES env variable

gDRcore 0.1.1.21 - 2022-01-03

• speed-up functions for mapping treated and untreated cases

gDRcore 0.1.1.20 - 2021-12-30

• fix linter issues

gDRcore 0.1.1.19 - 2021-12-14

• use parallel computing as an alternative for for loops

gDRcore 0.1.1.18 - 2021-12-07

• update annotation script as per new csv annotation files

gDRcore 0.1.1.17 - 2021-12-07

• detect co-trt data and treat them as single-agent

gDRcore 0.1.1.16 - 2021-11-08

• set excess = NA for single-agent

gDRcore 0.1.1.15 - 2021-10-29

• solve rounding issues
• add new bliss metric

gDRcore 0.1.1.14 - 2021-10-25

• refactor isobolograms

gDRcore 0.1.1.13 - 2021-10-25

• move p_trt_keys to the proper place

gDRcore 0.1.1.12 - 2021-10-20

• add support for masked data in fit_SE.combinations.R

gDRcore 0.1.1.11 - 2021-10-14

• address issues in creating the SE for combo matrix experiments

gDRcore 0.1.1.10 - 2021-10-13

• refactor the logic for calculation Loewe when there is no Concentration == 0

gDRcore 0.1.1.9 - 2021-10-12

• refactor the logic for combo data

gDRcore 0.1.1.8 - 2021-09-27

• update normalization_types in ‘calculate_combo_matrix’ and ‘fit_SE’

gDRcore 0.1.1.7 - 2021-09-21

• calculate_GR_value by removing cl_name param

gDRcore 0.1.1.6 - 2021-08-25

• fix but with missing nested_identifiers variables for creating DataFrame for masked values

gDRcore 0.1.1.5 - 2021-08-04

• refactor reading annotations and add default parameters

gDRcore 0.1.1.4 - 2021-07-30

• fix bug for nested_confounders not present in ref_df

gDRcore 0.1.1.3 - 2021-07-27

• add support for nested_identifiers and nested_confounders

gDRcore 0.1.1.2 - 2021-07-23

• remove obsolete dependencies from DESCRIPTION:Imports

gDRcore 0.1.0.9 - 2021-07-01

• function for testing synthetic data

gDRcore 0.1.0.8 - 2021-06-25

• move functions for importing template files to gDRimport package

gDRcore 0.1.0.7 - 2021-06-23

• add linter
• remove obsolete functions from test.utils.R

gDRcore 0.1.0.6 - 2021-06-22

• move importing functions to gDRimport package

gDRcore 0.1.0.5 - 2021-06-14

• add unit tests for synthetic data

gDRcore 0.1.0.4 - 2021-06-14

• remove deprecated functions and unit tests

gDRcore 0.1.0.3 - 2021-06-14

• update namespace for ‘metadata-’

gDRcore 0.1.0.2 - 2021-06-10

• change package name - gDR => gDRcore

gDRcore 0.1.0.1 - 2021-06-04

• export/update docs for ‘standardize_record_values’

gDRcore 0.1.0.0 - 2021-06-02

• release 1.0.0

gDRcore 0.0.1.52 - 2021-04-29

• remove all the gDRinternal-related files

gDRcore 0.0.1.51 - 2021-04-27

• fix wrong argument name in fit_curves

gDRcore 0.0.1.50 - 2021-04-23

• ensure that dts in assay- se,"Averaged" are NULL when there are not treatments

gDRcore 0.0.1.49 - 2021-04-20

• add processing info metadata to SE

gDRcore 0.0.1.48 - 2021-04-14

• improve handling of nested_keys and override_controls

gDRcore 0.0.1.47 - 2021-04-09

• get rid of sorting index columns in getMetaData

gDRcore 0.0.1.46 - 2021-03-31

• move SE metadata getters and setters to gDRutils

gDRcore 0.0.1.45 - 2021-03-31

• fix a bug in map_df function

gDRcore 0.0.1.44 - 2021-03-26

• refactor processing functions in create_SE2, normalize_SE2, average_SE2, and fit_SE2 and friends

gDRcore 0.0.1.43 - 2021-02-22

• add drug_moa_2 to merged df

gDRcore 0.0.1.42 - 2021-02-17

• fix a bug with adding annotation to codrugs

gDRcore 0.0.1.41 - 2021-02-04

• add script for benchmarking [normalize/average/metrics]-SE functions

gDRcore 0.0.1.40 - 2021-02-02

• fix unit tests
• include discard keys info in getMetaData for rowData

gDRcore 0.0.1.39 - 2021-01-29

• utilize refactored and renamed fitting function RVGRfit to fit_curves

gDRcore 0.0.1.38 - 2021-01-27

• export some functions for use in gDRutils

gDRcore 0.0.1.37 - 2021-01-20

• move df_to_assay and df_to_bm_assay to gDRutils

gDRcore 0.0.1.36 - 2021-01-18

• update rowData and colData in SE with additional columns

gDRcore 0.0.1.35 - 2021-01-14

• update positional header calls to explicit identifier calls
• apply minor changes to comply with gDRstyle
• apply minor changes to use identifiers over hard coded DrugName requirements

gDRcore 0.0.1.34 - 2021-01-12

• update scripts related to annotation of drugs and cell lines

gDRcore 0.0.1.33 - 2021-01-05

• anonymize test data

gDRcore 0.0.1.32 - 2020-12-24

• switch from GeneDataScreenR to gDRinternal from QCS to gDR functions

gDRcore 0.0.1.31 - 2020-12-22

• make createSE returning assays as ‘BumpyMatrix’ objects - previously ‘matrix’ objects only
• add df_to_bm_assay function - returning BumpyMatrix object from raw experiment data
• add initial tests for createSE function

gDRcore 0.0.1.30 - 2020-12-21

• clean up minor issues

gDRcore 0.0.1.29 - 2020-12-15

• remove dplyr
• use the latest version of gDRutils

gDRcore 0.0.1.28 - 2020-12-07

• error messages

gDRcore 0.0.1.27 - 2020-12-02

• refactor analyze_data.R with taking account codilution combo

gDRcore 0.0.1.26 - 2020-11-24

• bug with reading raw data

gDRcore 0.0.1.25 - 2020-11-08

• clean-up repository from duplicated functions

gDRcore 0.0.1.25 - 2020-11-06

• switch to R 4.0

gDRcore 0.0.1.24 - 2020-10-01

• bugs in function for metrics calculation as per QCS dataset
• QCS data
• scripts for processing and pushing QCS data on Rosalind

gDRcore 0.0.1.23 - 2020-09-29

• update README.md

gDRcore 0.0.1.22 - 2020-09-22

• bug in update_experiment_metadata

gDRcore 0.0.1.21 - 2020-09-03

• logic as per new db model

gDRcore 0.0.1.20 - 2020-08-26

• RDS files for the other GDS data - GDS5, GDS6, GDS7

gDRcore 0.0.1.19 - 2020-08-03

• support an import of single agent data from GDS
  • including the masked field to be able to remove the masked data from averages
  • add a function to annotate drug combinations - add_codrug_group
  • update the tests that contained combination experiments accordingly.
  • add new tests for the GDS data
  • minor refactor to use the ‘masked’ column. If it is not part of the initial dataframe it is added automatically - and set to FALSE

gDRcore 0.0.1.18 - 2020-07-29

• fixed issue in update_experiment_metadata.R
• unit test for update_experiment_metadata.R

gDRcore 0.0.1.17 - 2020-07-14

• function for updating metadata in SE

gDRcore 0.0.1.16 - 2020-07-14

• dependencies: kcloak, gDRwrapper

gDRcore 0.0.1.15 - 2020-07-08

• dependencies