PRISM Broad Screen Cancer Cell Line Viability Dataset — PRISMBroadScreen_Hagenbeek_NatComm_2026 • gDRtestData

The single-agent screening data from the PRISM platform - with one drug and 774 cell lines.

Format

A MultiAssayExperiment object containing a single-agent experiment with 5 assays.

Source

Hagenbeek et al, Nat Comm 2026, Accepted

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gDRutils::get_synthetic_data("prism")

Description

Assays

Experimental data matrices tracking cell line viability across processing stages:

RawTreated: Raw intensity values for treated cell line pools.
Controls: Raw intensity values for DMSO and killing controls.
Normalized: Viability scores relative to controls.
Averaged: Replicate-averaged viability scores.
Metrics: Dose-response curve parameters (e.g., IC50, AUC).

Column Metadata (colData)

Feature metadata describing the cell lines (models) across assays:

clid: Unique Broad Institute cell line identifier.
CellLineName: Publicly recognized cancer cell line name.
Tissue: Primary tissue of origin.
parental_identifier: Identifier for the parental cell line.
subtype: Histological or molecular subtype.
ReferenceDivisionTime: Estimated doubling time in hours.

Row Metadata (rowData)

Feature metadata describing the treatment compounds across assays:

Gnumber: Genentech compound identifier.
DrugName: Public or commercial name of the tested compound.
drug_moa: Mechanism of action / biological target of the drug.
Duration: Exposure time of the cell lines to the compound (e.g., 72h).