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Somatic Mutations (Hotspot)

Source: R/dataset.R
DepMap_OmicsSomaticMutationsMatrixHotspot.Rd

Binary matrix of known hotspot mutations from whole exome sequencing.

Format

Matrix with cell lines as rows and genes as columns

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data.table::fread(system.file("depmap_data/OmicsSomaticMutationsMatrixHotspot.csv.gz", package = "gDRtestData"))

Description

  • Rows: Cell line identifiers

  • Columns: NCBI gene IDs

  • Values: Binary (0 = no mutation, 1 = hotspot mutation)

  • Hotspots defined by COSMIC and OncoKB

Source

DepMap Portal - Data

Details

Downloaded May 26, 2026 from DepMap Portal (version 24Q4).

Citation: 24Q4 DepMap Release, including CRISPR Screens, PRISM Drug Screens, Copy Number, Mutation, Expression, and Fusions DepMap, Broad (2024). DepMap 24Q4 Public. Figshare+. Dataset. https://doi.org/10.25452/figshare.plus.27993248.v1