Set IC50/GR50 value to Inf or -Inf based on upper and lower limits.
Usage
cap_xc50(xc50, max_conc, min_conc = NA, capping_fold = 5)
Arguments
- xc50
Numeric value of the IC50/GR50 to cap.
- max_conc
Numeric value of the highest concentration in a dose series used to calculate the xc50.
- min_conc
Numeric value of the lowest concentration in a dose series used to calculate the xc50.
If NA (default), using max_conc/1e5 instead.
- capping_fold
Integer value of the fold number to use for capping. Defaults to 5.
Value
Capped IC50/GR50 value.
Details
Note: xc50 and max_conc should share the same units.
Ideally, the lower_cap should be based on the lowest tested concentration.
However, since we don't record that, it is set 5 orders of magnitude below the highest dose.
Examples
cap_xc50(xc50 = 1, max_conc = 2)
#> [1] 1
cap_xc50(xc50 = 2, max_conc = 5, min_conc = 1)
#> [1] 2
cap_xc50(xc50 = 26, max_conc = 5, capping_fold = 5)
#> [1] Inf