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Plot drug response curves for combo data

Source: R/plot-combo-response_curve.R
plot_dose_response_combo.Rd

Plot drug response curves for combo data

Usage

plot_dose_response_combo(
  dt_average,
  drug1_name,
  drug2_name,
  cl_name,
  normalization_type = "GR",
  colors_vec = NULL,
  split_by_conc = FALSE
)

Arguments

dt_average

data.table representing data from the Averaged assay, outputted by gDRutils::convert_se_assay_to_dt(se, "Averaged") and combo SummarizedExperiment

drug1_name

string with drug name to be plotted (identifiers DrugName)

drug2_name

string with co-drug name to be plotted (identifiers DrugName_2)

cl_name

string with cell line name to be plotted (identifiers CellLineName)

normalization_type

string with normalization_types to be selected one of: "GR" ("GRvalue") or "RV" ("RelativeViability")

colors_vec

character vector with colors for group_names - name or hex value note that the first color will be assigned to the min value of Concentration_2, and the last one - to the max of Concentration_2; the default is the orange-black palette

split_by_conc

split_by_conc logical flag indicating whether curves for Concentration_2 should be plotted on a single plot or separately

Value

ggplot object containing plot with dose-response curves for combo data

Examples

mae <- gDRutils::get_synthetic_data("combo_matrix")
se <- mae[[gDRutils::get_supported_experiments("combo")]]
dt_average <- gDRutils::convert_se_assay_to_dt(se, "Averaged")

cl_name <- "cellline_BC"
drug1_name <- "drug_011"
drug2_name <- "drug_021"

plot_dose_response_combo(dt_average = dt_average,
                         drug1_name = drug1_name,
                         drug2_name = drug2_name,
                         cl_name = cl_name)


plot_dose_response_combo(dt_average = dt_average,
                         drug1_name = drug1_name,
                         drug2_name = drug2_name,
                         cl_name = cl_name,
                         split_by_conc = TRUE)


plot_dose_response_combo(dt_average = dt_average,
                         drug1_name = drug1_name,
                         drug2_name = drug2_name,
                         cl_name = cl_name,
                         normalization_type = "RV",
                         colors_vec = c("lightblue", "darkblue"))